Assay Detail
Binding
CHEMBL4675308
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H][Ile5,6]deltorphin II from delta opioid receptor in rat brain membranes incubated for 45 mins by liquid scintillation counting method
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, Biological, and Structural Explorations of New Zwitterionic Derivatives of 14- O-Methyloxymorphone, as Potent μ/δ Opioid Agonists and Peripherally Selective Antinociceptives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 42 | 8.32 | 8.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4755067 | — | — | 1 | 8.99 |
| CHEMBL4795312 | — | — | 1 | 8.99 |
| CHEMBL4789014 | — | — | 1 | 8.92 |
| CHEMBL4788003 | — | — | 1 | 8.92 |
| CHEMBL4783612 | — | — | 1 | 8.92 |
| CHEMBL4793888 | — | — | 1 | 8.90 |
| CHEMBL4781006 | — | — | 1 | 8.89 |
| CHEMBL4750229 | — | — | 1 | 8.89 |
| CHEMBL4792012 | — | — | 1 | 8.86 |
| CHEMBL4795517 | — | — | 1 | 8.78 |
| CHEMBL4741203 | — | — | 1 | 8.71 |
| CHEMBL4753934 | — | — | 1 | 8.66 |
| CHEMBL4760163 | — | — | 1 | 8.65 |
| CHEMBL4741873 | — | — | 1 | 8.48 |
| CHEMBL4761784 | — | — | 1 | 8.47 |
| CHEMBL4782629 | — | — | 1 | 8.45 |
| CHEMBL4754944 | — | — | 1 | 8.44 |
| CHEMBL4757240 | — | — | 1 | 8.43 |
| CHEMBL4745745 | — | — | 1 | 8.41 |
| CHEMBL4793953 | — | — | 1 | 8.41 |
| CHEMBL607405 | — | — | 1 | 8.32 |
| CHEMBL4763225 | — | — | 1 | 8.31 |
| CHEMBL4755501 | — | — | 1 | 8.29 |
| CHEMBL4788604 | — | — | 1 | 8.28 |
| CHEMBL4741308 | — | — | 1 | 8.27 |
| CHEMBL4740464 | — | — | 1 | 8.18 |
| CHEMBL4754111 | — | — | 1 | 8.12 |
| CHEMBL4740918 | — | — | 1 | 8.12 |
| CHEMBL4763643 | — | — | 1 | 8.11 |
| CHEMBL4755734 | — | — | 1 | 8.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4755067 | — | Ki | = | 1.02 | nM | 8.99 |
| CHEMBL4795312 | — | Ki | = | 1.03 | nM | 8.99 |
| CHEMBL4788003 | — | Ki | = | 1.19 | nM | 8.92 |
| CHEMBL4783612 | — | Ki | = | 1.19 | nM | 8.92 |
| CHEMBL4789014 | — | Ki | = | 1.19 | nM | 8.92 |
| CHEMBL4793888 | — | Ki | = | 1.27 | nM | 8.90 |
| CHEMBL4781006 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL4750229 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL4792012 | — | Ki | = | 1.38 | nM | 8.86 |
| CHEMBL4795517 | — | Ki | = | 1.68 | nM | 8.78 |
| CHEMBL4741203 | — | Ki | = | 1.93 | nM | 8.71 |
| CHEMBL4753934 | — | Ki | = | 2.18 | nM | 8.66 |
| CHEMBL4760163 | — | Ki | = | 2.25 | nM | 8.65 |
| CHEMBL4741873 | — | Ki | = | 3.34 | nM | 8.48 |
| CHEMBL4761784 | — | Ki | = | 3.37 | nM | 8.47 |
| CHEMBL4782629 | — | Ki | = | 3.52 | nM | 8.45 |
| CHEMBL4754944 | — | Ki | = | 3.67 | nM | 8.44 |
| CHEMBL4757240 | — | Ki | = | 3.69 | nM | 8.43 |
| CHEMBL4745745 | — | Ki | = | 3.89 | nM | 8.41 |
| CHEMBL4793953 | — | Ki | = | 3.91 | nM | 8.41 |
| CHEMBL607405 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL4763225 | — | Ki | = | 4.87 | nM | 8.31 |
| CHEMBL4755501 | — | Ki | = | 5.13 | nM | 8.29 |
| CHEMBL4788604 | — | Ki | = | 5.29 | nM | 8.28 |
| CHEMBL4741308 | — | Ki | = | 5.32 | nM | 8.27 |
| CHEMBL4740464 | — | Ki | = | 6.61 | nM | 8.18 |
| CHEMBL4754111 | — | Ki | = | 7.52 | nM | 8.12 |
| CHEMBL4740918 | — | Ki | = | 7.64 | nM | 8.12 |
| CHEMBL4763643 | — | Ki | = | 7.71 | nM | 8.11 |
| CHEMBL4755734 | — | Ki | = | 7.86 | nM | 8.11 |
| CHEMBL4761211 | — | Ki | = | 9.03 | nM | 8.04 |
| CHEMBL4777389 | — | Ki | = | 10.4 | nM | 7.98 |
| CHEMBL4780909 | — | Ki | = | 11.3 | nM | 7.95 |
| CHEMBL4743953 | — | Ki | = | 12.5 | nM | 7.90 |
| CHEMBL4757463 | — | Ki | = | 13.9 | nM | 7.86 |
| CHEMBL4748047 | — | Ki | = | 14.3 | nM | 7.84 |
| CHEMBL4740360 | — | Ki | = | 14.6 | nM | 7.84 |
| CHEMBL1672084 | — | Ki | = | 15.4 | nM | 7.81 |
| CHEMBL4747179 | — | Ki | = | 22.6 | nM | 7.65 |
| CHEMBL4782642 | — | Ki | = | 26.9 | nM | 7.57 |
| CHEMBL4797321 | — | Ki | = | 37.5 | nM | 7.43 |
| CHEMBL4776879 | — | Ki | = | 60.0 | nM | 7.22 |