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Assay Detail

CHEMBL4679983

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Inhibition of human CYP2C9
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cytochrome P450 2C9 (CHEMBL3397)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery and Preclinical Evaluation of BMS-986242, a Potent, Selective Inhibitor of Indoleamine-2,3-dioxygenase 1.
Cherney EC,Zhang L,Nara S,Zhu X,Gullo-Brown J,Maley D,Lin TA,Hunt JT,Huang C,Yang Z,Darienzo C,Discenza L,Ranasinghe A,Grubb M,Ziemba T,Traeger SC,Li X,Johnston K,Kopcho L,Fereshteh M,Foster K,Stefanski K,Fargnoli J,Swanson J,Brown J,Delpy D,Seitz SP,Borzilleri R,Vite G,Balog A
ACS Med Chem Lett (2021) 12 : 288 -294
PubMed 33603977 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 6.13 6.13

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4786690 1 6.13

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4786690 IC50 = 740.0 nM 6.13