Assay Detail
Functional
CHEMBL4681605
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Growth inhibition of human A2780 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Potent Antitumor Activities and Structure Basis of the Chiral β-Lactam Bridged Analogue of Combretastatin A-4 Binding to Tubulin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.00 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.22 |
| CHEMBL4285231 | — | — | 1 | 7.51 |
| CHEMBL4793994 | — | — | 1 | 6.94 |
| CHEMBL4762438 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4285231 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4793994 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL4762438 | — | IC50 | = | 4600.0 | nM | 5.34 |