Assay Detail
Binding
CHEMBL4681685
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Inhibition of wild-type androgen receptor in human LAPC4 cells assessed as inhibition of DHT-induced luciferase activity measured after 24 hrs by luciferase reporter assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | LAPC4 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Revisiting the SAR of the Antischistosomal Aryl Hydantoin (Ro 13-3978).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 5.61 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4799175 | — | — | 1 | 6.85 |
| CHEMBL4793070 | — | — | 1 | 6.58 |
| CHEMBL4758277 | — | — | 1 | 6.54 |
| CHEMBL1274 | NILUTAMIDE | 4.0 | 1 | 6.22 |
| CHEMBL4787997 | — | — | 1 | 6.04 |
| CHEMBL4755665 | — | — | 1 | 6.00 |
| CHEMBL4750103 | — | — | 1 | 5.89 |
| CHEMBL4778974 | — | — | 1 | 5.89 |
| CHEMBL4778298 | — | — | 1 | 5.89 |
| CHEMBL4790269 | — | — | 1 | 5.68 |
| CHEMBL4786505 | — | — | 1 | 5.62 |
| CHEMBL4786811 | — | — | 1 | 5.55 |
| CHEMBL4572306 | — | — | 1 | 5.51 |
| CHEMBL4778185 | — | — | 1 | 5.46 |
| CHEMBL4799429 | — | — | 1 | 5.43 |
| CHEMBL4782426 | — | — | 1 | 5.42 |
| CHEMBL4747499 | — | — | 1 | 5.38 |
| CHEMBL4743529 | — | — | 1 | 5.38 |
| CHEMBL4748557 | — | — | 1 | 5.37 |
| CHEMBL4465426 | — | — | 1 | 5.36 |
| CHEMBL4748422 | — | — | 1 | 5.35 |
| CHEMBL4793158 | — | — | 1 | 5.32 |
| CHEMBL4763136 | — | — | 1 | 5.28 |
| CHEMBL4781708 | — | — | 1 | 5.22 |
| CHEMBL4740944 | — | — | 1 | 5.20 |
| CHEMBL4777133 | — | — | 1 | 5.16 |
| CHEMBL4777511 | — | — | 1 | 5.09 |
| CHEMBL4746443 | — | — | 1 | 5.04 |
| CHEMBL4763876 | — | — | 1 | 5.02 |
| CHEMBL4779897 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4799175 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4793070 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4758277 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1274 | NILUTAMIDE | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4787997 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL4755665 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL4750103 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4778974 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4778298 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4790269 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4786505 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4786811 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4572306 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4778185 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4799429 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL4782426 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4747499 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4743529 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4748557 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4465426 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4748422 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4793158 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4763136 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL4781708 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4740944 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4777133 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL4777511 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL4746443 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL4763876 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL976 | PRAZIQUANTEL | IC50 | - | — | - | |
| CHEMBL4795534 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4754845 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4782196 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4756377 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4744974 | — | IC50 | >= | 10000.0 | nM | - |
| CHEMBL4747544 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4743225 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4779897 | — | IC50 | - | — | - |