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Compound Detail

CHEMBL4786811

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CC1(C)C(=O)NC(=O)N1c1ccc(F)c(C(F)(F)F)c1

Basic Information

ChEMBL ID CHEMBL4786811
Phase Preclinical
Structure Type MOL
InChI Key WLIGSOAERKSNQE-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
2
PK Parameters
6
Publications
0
Known Names

Molecular Properties

290.2
MW (Da)
2.68
ALogP
2
HBA
1
HBD
49.4
PSA (Ų)
0.64
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C12H10F4N2O2
MW 290.22
Aromatic Rings 1
Heavy Atoms 20
NP-Likeness -1.35

Activity Summary

IC50 1 meas. best 5.55

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Androgen receptor
CHEMBL1871
IC50 5.55 5.55 2800.0 1

Pharmacokinetic Data

Parameter Value Units Species
CL 7.0 mL.min-1.g-1 Homo sapiens
CL 7.0 mL.min-1.g-1 Mus musculus

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Androgen receptor IC50 = 2800.0 nM 5.55 Inhibition of wild-type androgen receptor in human LAPC4 cells assessed as inhib... 27933964

Literature References

Data from ChEMBL 36 via Core Engine