Assay Detail
Binding
CHEMBL4682779
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Inhibition of PDIA4 (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 1 hr and measured by insulin reduction assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tuning isoform selectivity and bortezomib sensitivity with a new class of alkenyl indene PDI inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.35 | 4.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4751979 | — | — | 1 | 4.48 |
| CHEMBL4751241 | — | — | 1 | 4.21 |
| CHEMBL4762045 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4751979 | — | IC50 | = | 33100.0 | nM | 4.48 |
| CHEMBL4751241 | — | IC50 | = | 61600.0 | nM | 4.21 |
| CHEMBL4762045 | — | IC50 | > | 100000.0 | nM | - |