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Compound Detail

CHEMBL4751241

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CCCCCCCC/C=C1/C=C(C(F)(F)F)c2cc(OC)c(OC)cc21

Basic Information

ChEMBL ID CHEMBL4751241
Phase Preclinical
Structure Type MOL
InChI Key QXPZBSKLHCUGFX-PTNGSMBKSA-N
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

368.4
MW (Da)
6.80
ALogP
2
HBA
0
HBD
18.5
PSA (Ų)
0.45
QED
1
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H27F3O2
MW 368.44
Aromatic Rings 1
Heavy Atoms 26
NP-Likeness 0.56

Activity Summary

IC50 4 meas. best 5.95

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
IC50 5.95 5.95 1120.0 1
Protein disulfide-isomerase A6
CHEMBL2146308
IC50 4.79 4.79 16300.0 1
Protein disulfide-isomerase A3
CHEMBL4296001
IC50 4.68 4.68 20800.0 1
Protein disulfide-isomerase A4
CHEMBL4295717
IC50 4.21 4.21 61600.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
31787362 10.1016/j.ejmech.2019.111906 Unchecked 6
31787362 10.1016/j.ejmech.2019.111906 Protein disulfide-isomerase A3 1
31787362 10.1016/j.ejmech.2019.111906 Protein disulfide-isomerase A4 1
31787362 10.1016/j.ejmech.2019.111906 Thioredoxin domain-containing protein 5 1
31787362 10.1016/j.ejmech.2019.111906 Protein disulfide-isomerase A6 1

Data from ChEMBL 36 via Core Engine