Assay Detail
Binding
CHEMBL4685299
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]Ile5'6-deltorphin II from DOR in Wistar rat brain membranes measured after 45 mins by scintillation counting method
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, biochemical, pharmacological characterization and in silico profile modelling of highly potent opioid orvinol and thevinol derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.96 | 8.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4746512 | — | — | 1 | 8.83 |
| CHEMBL4776706 | — | — | 1 | 8.73 |
| CHEMBL4751305 | — | — | 1 | 8.69 |
| CHEMBL4754079 | — | — | 1 | 8.68 |
| CHEMBL4745764 | — | — | 1 | 8.62 |
| CHEMBL4753839 | — | — | 1 | 8.61 |
| CHEMBL4762529 | — | — | 1 | 8.11 |
| CHEMBL4761619 | — | — | 1 | 7.80 |
| CHEMBL4758814 | — | — | 1 | 7.58 |
| CHEMBL4764372 | — | — | 1 | 7.56 |
| CHEMBL4752367 | — | — | 1 | 7.44 |
| CHEMBL4758369 | — | — | 1 | 7.43 |
| CHEMBL4787652 | — | — | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4746512 | — | Ki | = | 1.49 | nM | 8.83 |
| CHEMBL4776706 | — | Ki | = | 1.85 | nM | 8.73 |
| CHEMBL4751305 | — | Ki | = | 2.06 | nM | 8.69 |
| CHEMBL4754079 | — | Ki | = | 2.11 | nM | 8.68 |
| CHEMBL4745764 | — | Ki | = | 2.41 | nM | 8.62 |
| CHEMBL4753839 | — | Ki | = | 2.44 | nM | 8.61 |
| CHEMBL4762529 | — | Ki | = | 7.73 | nM | 8.11 |
| CHEMBL4761619 | — | Ki | = | 15.72 | nM | 7.80 |
| CHEMBL4758814 | — | Ki | = | 26.12 | nM | 7.58 |
| CHEMBL4764372 | — | Ki | = | 27.53 | nM | 7.56 |
| CHEMBL4752367 | — | Ki | = | 36.56 | nM | 7.44 |
| CHEMBL4758369 | — | Ki | = | 37.37 | nM | 7.43 |
| CHEMBL4787652 | — | Ki | = | 3906.3 | nM | 5.41 |