Assay Detail
Functional
CHEMBL4687828
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Cytotoxicity in human U87 cells assessed as reduction in cell viability incubated for 2 hrs by Cell-titer-blue assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-87MG ATCC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Doxorubicin and Aclarubicin: Shuffling Anthracycline Glycans for Improved Anticancer Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.41 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4785287 | — | — | 1 | 7.48 |
| CHEMBL3301909 | — | — | 1 | 7.23 |
| CHEMBL502620 | ACLARUBICIN | 3.0 | 1 | 6.86 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.42 |
| CHEMBL4798940 | — | — | 1 | 6.35 |
| CHEMBL4762286 | — | — | 1 | 6.22 |
| CHEMBL4762068 | — | — | 1 | 5.66 |
| CHEMBL4757229 | — | — | 1 | 5.05 |
| CHEMBL4743488 | — | — | 1 | - |
| CHEMBL4796372 | — | — | 1 | - |
| CHEMBL4799572 | — | — | 1 | - |
| CHEMBL4753332 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4785287 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3301909 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL502620 | ACLARUBICIN | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 381.0 | nM | 6.42 |
| CHEMBL4798940 | — | IC50 | = | 448.0 | nM | 6.35 |
| CHEMBL4762286 | — | IC50 | = | 603.0 | nM | 6.22 |
| CHEMBL4762068 | — | IC50 | = | 2213.0 | nM | 5.66 |
| CHEMBL4757229 | — | IC50 | = | 8847.0 | nM | 5.05 |
| CHEMBL4743488 | — | IC50 | - | — | - | |
| CHEMBL4796372 | — | IC50 | - | — | - | |
| CHEMBL4799572 | — | IC50 | - | — | - | |
| CHEMBL4753332 | — | IC50 | - | — | - |