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Assay Detail

CHEMBL4688556

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]-citalopram from human SERT by liquid scintillation counting
22
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Sodium-dependent serotonin transporter (CHEMBL228)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

A study of the structure-affinity relationship in SYA16263; is a D receptor interaction essential for inhibition of apormorphine-induced climbing behavior in mice?
Onyameh EK,Bricker BA,Eyunni SVK,Voshavar C,Gonela UM,Ofori E,Jenkins A,Ablordeppey SY
Bioorg Med Chem (2021) 30 : 115943 -115943
PubMed 33338898 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 22 6.53 7.63

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4558031 2 7.63
CHEMBL1946124 2 7.62
CHEMBL4574793 2 7.43
CHEMBL4474014 2 7.19
CHEMBL4746695 1 6.80
CHEMBL4789472 2 6.62
CHEMBL4570411 2 6.03
CHEMBL1112 ARIPIPRAZOLE 4.0 1 5.97
CHEMBL4762416 2 5.66
CHEMBL4783987 2 5.57
CHEMBL3289648 2 5.53
CHEMBL4743284 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4558031 Ki = 23.44 nM 7.63
CHEMBL1946124 Ki = 23.99 nM 7.62
CHEMBL4558031 Ki = 24.0 nM 7.62
CHEMBL1946124 Ki = 24.0 nM 7.62
CHEMBL4574793 Ki = 37.15 nM 7.43
CHEMBL4574793 Ki = 37.0 nM 7.43
CHEMBL4474014 Ki = 64.57 nM 7.19
CHEMBL4474014 Ki = 64.0 nM 7.19
CHEMBL4746695 Ki = 158.4 nM 6.80
CHEMBL4789472 Ki = 241.0 nM 6.62
CHEMBL4789472 Ki = 251.19 nM 6.60
CHEMBL4570411 Ki = 933.25 nM 6.03
CHEMBL4570411 Ki = 949.0 nM 6.02
CHEMBL1112 ARIPIPRAZOLE Ki = 1080.0 nM 5.97
CHEMBL4762416 Ki = 2204.0 nM 5.66
CHEMBL4783987 Ki = 2691.53 nM 5.57
CHEMBL4783987 Ki = 2667.0 nM 5.57
CHEMBL3289648 Ki = 2987.0 nM 5.53
CHEMBL3289648 Ki = 3019.95 nM 5.52
CHEMBL4762416 Ki = 8709.64 nM 5.06
CHEMBL4743284 Ki > 10000.0 nM -
CHEMBL4743284 Ki > 10000.0 nM -