Assay Detail
Functional
CHEMBL4688809
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV-3B infected in human MT-4 cells assessed as reduction in virus-induced cytopathic effect incubated for 5 days by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Novel indolylarylsulfone derivatives as covalent HIV-1 reverse transcriptase inhibitors specifically targeting the drug-resistant mutant Y181C.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 6.30 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL175691 | RILPIVIRINE | 4.0 | 1 | 8.00 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 8.00 |
| CHEMBL253629 | — | — | 1 | 5.44 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 5.07 |
| CHEMBL4760121 | — | — | 1 | 5.01 |
| CHEMBL4752899 | — | — | 1 | - |
| CHEMBL4751528 | — | — | 1 | - |
| CHEMBL4762273 | — | — | 1 | - |
| CHEMBL4798626 | — | — | 1 | - |
| CHEMBL4741996 | — | — | 1 | - |
| CHEMBL4796270 | — | — | 1 | - |
| CHEMBL4754387 | — | — | 1 | - |
| CHEMBL4755224 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL175691 | RILPIVIRINE | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL253629 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL4760121 | — | EC50 | = | 9740.0 | nM | 5.01 |
| CHEMBL4752899 | — | EC50 | > | 6500.0 | nM | - |
| CHEMBL4751528 | — | EC50 | > | 2100.0 | nM | - |
| CHEMBL4762273 | — | EC50 | > | 51800.0 | nM | - |
| CHEMBL4798626 | — | EC50 | > | 43600.0 | nM | - |
| CHEMBL4741996 | — | EC50 | = | 125400.0 | nM | - |
| CHEMBL4796270 | — | EC50 | > | 155200.0 | nM | - |
| CHEMBL4754387 | — | EC50 | > | 178000.0 | nM | - |
| CHEMBL4755224 | — | EC50 | > | 29000.0 | nM | - |