Assay Detail
Binding
CHEMBL4699694
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated with enzyme for 6 mins followed by substrate addition and measured for 180 secs by Ellman's method
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chromone and donepezil hybrids as new multipotent cholinesterase and monoamine oxidase inhibitors for the potential treatment of Alzheimer''s disease
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.40 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4798359 | — | — | 1 | 6.35 |
| CHEMBL4794092 | — | — | 1 | 6.28 |
| CHEMBL4755016 | — | — | 1 | 6.22 |
| CHEMBL4756552 | — | — | 1 | 6.04 |
| CHEMBL4762012 | — | — | 1 | 5.93 |
| CHEMBL4798406 | — | — | 1 | 5.91 |
| CHEMBL4286799 | — | — | 1 | 5.81 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 5.61 |
| CHEMBL4762982 | — | — | 1 | 5.28 |
| CHEMBL4749888 | — | — | 1 | 5.03 |
| CHEMBL4782785 | — | — | 1 | 5.01 |
| CHEMBL4760340 | — | — | 1 | 4.91 |
| CHEMBL4793623 | — | — | 1 | 4.82 |
| CHEMBL4757560 | — | — | 1 | 4.74 |
| CHEMBL4790953 | — | — | 1 | 4.73 |
| CHEMBL4741196 | — | — | 1 | 4.61 |
| CHEMBL4757818 | — | — | 1 | 4.55 |
| CHEMBL673 | PARGYLINE | 4.0 | 1 | - |
| CHEMBL92401 | IPRONIAZID | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4798359 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4794092 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL4755016 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4756552 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL4762012 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL4798406 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL4286799 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL4762982 | — | IC50 | = | 5240.0 | nM | 5.28 |
| CHEMBL4749888 | — | IC50 | = | 9450.0 | nM | 5.03 |
| CHEMBL4782785 | — | IC50 | = | 9780.0 | nM | 5.01 |
| CHEMBL4760340 | — | IC50 | = | 12430.0 | nM | 4.91 |
| CHEMBL4793623 | — | IC50 | = | 15270.0 | nM | 4.82 |
| CHEMBL4757560 | — | IC50 | = | 18240.0 | nM | 4.74 |
| CHEMBL4790953 | — | IC50 | = | 18670.0 | nM | 4.73 |
| CHEMBL4741196 | — | IC50 | = | 24360.0 | nM | 4.61 |
| CHEMBL4757818 | — | IC50 | = | 27860.0 | nM | 4.55 |
| CHEMBL673 | PARGYLINE | IC50 | - | — | - | |
| CHEMBL92401 | IPRONIAZID | IC50 | - | — | - |