Assay Detail
Functional
CHEMBL4700083
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against recombinant Trypanosoma cruzi intracellular amastigotes expressing beta-galactosidase infected in mouse NIH/3T3 cells assessed as parasite growth inhibition incubated for 4 days by resorufin-beta-D-galactopiranoside substrate based fluorescence assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Cell Type | NIH/3T3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Hit-to-lead optimization of novel benzimidazole phenylacetamides as broad spectrum trypanosomacides
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.20 | 6.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3431111 | — | — | 1 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3431111 | — | IC50 | = | 630.0 | nM | 6.20 |