Assay Detail
Functional
CHEMBL4700266
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Trypanocidal activity against Trypanosoma cruzi Tulahuen LacZ intracellular amastigote form infected in monkey LLC-MK2 cells incubated for 72 hrs by chlorophenol red beta-D-galactopyranoside substrate based spectrophotometric assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Cell Type | LLC-MK2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
On the intrinsic reactivity of highly potent trypanocidal cruzain inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 4.76 | 5.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12980 | QUINUCLIDINYL BENZILATE | — | 1 | 5.37 |
| CHEMBL4217414 | — | — | 1 | 5.08 |
| CHEMBL604281 | — | — | 1 | 4.66 |
| CHEMBL4208861 | — | — | 1 | 4.59 |
| CHEMBL4213366 | — | — | 1 | 4.10 |
| CHEMBL344174 | — | — | 1 | - |
| CHEMBL4463665 | — | — | 1 | - |
| CHEMBL371466 | — | — | 1 | - |
| CHEMBL4747490 | — | — | 1 | - |
| CHEMBL4750144 | — | — | 1 | - |
| CHEMBL4776689 | — | — | 1 | - |
| CHEMBL4789329 | — | — | 1 | - |
| CHEMBL4208600 | — | — | 1 | - |
| CHEMBL4213247 | — | — | 1 | - |
| CHEMBL4217658 | — | — | 1 | - |
| CHEMBL4209401 | — | — | 1 | - |
| CHEMBL4203721 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12980 | QUINUCLIDINYL BENZILATE | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4217414 | — | EC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL604281 | — | EC50 | = | 21700.0 | nM | 4.66 |
| CHEMBL4208861 | — | EC50 | = | 25800.0 | nM | 4.59 |
| CHEMBL4213366 | — | EC50 | = | 79600.0 | nM | 4.10 |
| CHEMBL344174 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4463665 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL371466 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4747490 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4750144 | — | EC50 | - | — | - | |
| CHEMBL4776689 | — | EC50 | - | — | - | |
| CHEMBL4789329 | — | EC50 | - | — | - | |
| CHEMBL4208600 | — | EC50 | - | — | - | |
| CHEMBL4213247 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4217658 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4209401 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4203721 | — | EC50 | > | 100000.0 | nM | - |