Assay Detail
Functional
CHEMBL4700533
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LPS-induced TNFalpha production in human THP-1 cells incubated for 2 hrs followed by LPS stimulation and measured after 12 hrs by ELISA
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological screening of a library of macamides as TNF-alpha inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 5.58 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4741016 | — | — | 1 | 8.05 |
| CHEMBL4744906 | — | — | 1 | 7.30 |
| CHEMBL4780964 | — | — | 1 | 7.22 |
| CHEMBL4760560 | — | — | 1 | 7.10 |
| CHEMBL4786583 | — | — | 1 | 6.96 |
| CHEMBL4744685 | — | — | 1 | 6.48 |
| CHEMBL4791162 | — | — | 1 | 6.27 |
| CHEMBL4787109 | — | — | 1 | 6.21 |
| CHEMBL4778317 | — | — | 1 | 6.15 |
| CHEMBL4795304 | — | — | 1 | 6.13 |
| CHEMBL4749337 | — | — | 1 | 6.11 |
| CHEMBL4743882 | — | — | 1 | 6.11 |
| CHEMBL4782222 | — | — | 1 | 6.01 |
| CHEMBL4798906 | — | — | 1 | 6.00 |
| CHEMBL4754239 | — | — | 1 | 5.92 |
| CHEMBL4757432 | — | — | 1 | 5.82 |
| CHEMBL4747955 | — | — | 1 | 5.80 |
| CHEMBL4762818 | — | — | 1 | 5.77 |
| CHEMBL4752695 | — | — | 1 | 5.75 |
| CHEMBL4778391 | — | — | 1 | 5.74 |
| CHEMBL250711 | OLEOYL DOPAMINE | — | 1 | 5.45 |
| CHEMBL4749287 | — | — | 1 | 5.28 |
| CHEMBL64379 | MALINAMIDE | — | 1 | 5.28 |
| CHEMBL4796598 | — | — | 1 | 5.19 |
| CHEMBL4780445 | — | — | 1 | 5.08 |
| CHEMBL4749407 | — | — | 1 | 5.05 |
| CHEMBL4749194 | — | — | 1 | 4.88 |
| CHEMBL2415106 | — | — | 1 | 4.85 |
| CHEMBL1223510 | — | — | 1 | 4.82 |
| CHEMBL4749954 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4741016 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4744906 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4780964 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4760560 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4786583 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4744685 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4791162 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL4787109 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL4778317 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL4795304 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL4743882 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL4749337 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL4782222 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL4798906 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4754239 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL4757432 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL4747955 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4762818 | — | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL4752695 | — | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL4778391 | — | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL250711 | OLEOYL DOPAMINE | IC50 | = | 3540.0 | nM | 5.45 |
| CHEMBL4749287 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL64379 | MALINAMIDE | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL4796598 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL4780445 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL4749407 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL4749194 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL2415106 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL1223510 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL4749954 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL2415104 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL4799813 | — | IC50 | = | 19700.0 | nM | 4.71 |
| CHEMBL4762255 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL4763119 | — | IC50 | = | 23800.0 | nM | 4.62 |
| CHEMBL2415102 | — | IC50 | = | 43100.0 | nM | 4.37 |
| CHEMBL4776118 | — | IC50 | = | 56800.0 | nM | 4.25 |
| CHEMBL4782107 | — | IC50 | = | 58700.0 | nM | 4.23 |
| CHEMBL1836706 | — | IC50 | = | 78400.0 | nM | 4.11 |
| CHEMBL8659 | OLEIC ACID | IC50 | = | 79000.0 | nM | 4.10 |