Assay Detail
Binding
CHEMBL4701864
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Agonist activity at human MOR expressed in human U2OS cells assessed as increase in beta arrestin2 recruitment incubated for 90 mins by pathhunter beta-arrestin assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | U2OS |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimized Opioid-Neurotensin Multitarget Peptides: From Design to Structure-Activity Relationship Studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 6.08 | 8.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3408737 | — | — | 1 | 8.26 |
| CHEMBL4745899 | — | — | 1 | 6.45 |
| CHEMBL4742666 | — | — | 1 | 6.03 |
| CHEMBL4761165 | — | — | 1 | 6.02 |
| CHEMBL4776986 | — | — | 1 | 5.97 |
| CHEMBL4798887 | — | — | 1 | 5.94 |
| CHEMBL4747286 | — | — | 1 | 5.90 |
| CHEMBL4789659 | — | — | 1 | 5.88 |
| CHEMBL4758754 | — | — | 1 | 5.71 |
| CHEMBL4750783 | — | — | 1 | 5.67 |
| CHEMBL4744531 | — | — | 1 | 5.61 |
| CHEMBL4749016 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3408737 | — | EC50 | = | 5.53 | nM | 8.26 |
| CHEMBL4745899 | — | EC50 | = | 359.0 | nM | 6.45 |
| CHEMBL4742666 | — | EC50 | = | 934.0 | nM | 6.03 |
| CHEMBL4761165 | — | EC50 | = | 956.0 | nM | 6.02 |
| CHEMBL4776986 | — | EC50 | = | 1066.0 | nM | 5.97 |
| CHEMBL4798887 | — | EC50 | = | 1142.0 | nM | 5.94 |
| CHEMBL4747286 | — | EC50 | = | 1271.0 | nM | 5.90 |
| CHEMBL4789659 | — | EC50 | = | 1329.0 | nM | 5.88 |
| CHEMBL4758754 | — | EC50 | = | 1965.0 | nM | 5.71 |
| CHEMBL4750783 | — | EC50 | = | 2163.0 | nM | 5.67 |
| CHEMBL4744531 | — | EC50 | = | 2459.0 | nM | 5.61 |
| CHEMBL4749016 | — | EC50 | = | 3044.0 | nM | 5.52 |