Assay Detail
Functional
CHEMBL4703002
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of APJ receptor (unknown origin) expressed in Chem-5 cells assessed as stimulation of Ca2+ mobilization by Calcium 6-GF dye based fluorescence based assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Chem-5 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimizing PEG-Extended Apelin Analogues as Cardioprotective Drug Leads: Importance of the KFRR Motif and Aromatic Head Group for Improved Physiological Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 8.03 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4787992 | — | — | 1 | 8.72 |
| CHEMBL4795982 | — | — | 1 | 8.62 |
| CHEMBL4740668 | — | — | 1 | 8.62 |
| CHEMBL4789383 | — | — | 1 | 8.60 |
| CHEMBL4775988 | — | — | 1 | 8.54 |
| CHEMBL4758442 | — | — | 1 | 8.46 |
| CHEMBL4763310 | — | — | 1 | 8.31 |
| CHEMBL4065973 | — | — | 1 | 8.31 |
| CHEMBL4753692 | — | — | 1 | 8.27 |
| CHEMBL4799454 | — | — | 1 | 8.21 |
| CHEMBL4744011 | — | — | 1 | 8.21 |
| CHEMBL4760648 | — | — | 1 | 8.11 |
| CHEMBL4755954 | — | — | 1 | 8.09 |
| CHEMBL4744024 | — | — | 1 | 7.77 |
| CHEMBL4788623 | — | — | 1 | 7.59 |
| CHEMBL4797426 | — | — | 1 | 7.40 |
| CHEMBL4794535 | — | — | 1 | 7.31 |
| CHEMBL4741692 | — | — | 1 | 7.27 |
| CHEMBL4745212 | — | — | 1 | 7.13 |
| CHEMBL4759447 | — | — | 1 | 7.05 |
| CHEMBL4761000 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4787992 | — | EC50 | = | 1.905 | nM | 8.72 |
| CHEMBL4795982 | — | EC50 | = | 2.399 | nM | 8.62 |
| CHEMBL4740668 | — | EC50 | = | 2.399 | nM | 8.62 |
| CHEMBL4789383 | — | EC50 | = | 2.512 | nM | 8.60 |
| CHEMBL4775988 | — | EC50 | = | 2.884 | nM | 8.54 |
| CHEMBL4758442 | — | EC50 | = | 3.467 | nM | 8.46 |
| CHEMBL4763310 | — | EC50 | = | 4.898 | nM | 8.31 |
| CHEMBL4065973 | — | EC50 | = | 4.898 | nM | 8.31 |
| CHEMBL4753692 | — | EC50 | = | 5.37 | nM | 8.27 |
| CHEMBL4799454 | — | EC50 | = | 6.166 | nM | 8.21 |
| CHEMBL4744011 | — | EC50 | = | 6.166 | nM | 8.21 |
| CHEMBL4760648 | — | EC50 | = | 7.762 | nM | 8.11 |
| CHEMBL4755954 | — | EC50 | = | 8.128 | nM | 8.09 |
| CHEMBL4744024 | — | EC50 | = | 16.98 | nM | 7.77 |
| CHEMBL4788623 | — | EC50 | = | 25.7 | nM | 7.59 |
| CHEMBL4797426 | — | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL4794535 | — | EC50 | = | 48.98 | nM | 7.31 |
| CHEMBL4741692 | — | EC50 | = | 53.7 | nM | 7.27 |
| CHEMBL4745212 | — | EC50 | = | 74.13 | nM | 7.13 |
| CHEMBL4759447 | — | EC50 | = | 89.13 | nM | 7.05 |
| CHEMBL4761000 | — | EC50 | > | 199.53 | nM | - |