Assay Detail
Binding
CHEMBL4703004
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]-pyr-1-apelin-13 from EGFP-tagged wild-type rat apelin receptor expressed in CHO cell membranes by gamma counting method
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | CHO |
| Subcellular | Cell membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimizing PEG-Extended Apelin Analogues as Cardioprotective Drug Leads: Importance of the KFRR Motif and Aromatic Head Group for Improved Physiological Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 9.00 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4787992 | — | — | 1 | 10.30 |
| CHEMBL4751860 | — | — | 1 | 9.70 |
| CHEMBL4764067 | — | — | 1 | 9.66 |
| CHEMBL4786278 | — | — | 1 | 9.53 |
| CHEMBL4795982 | — | — | 1 | 9.52 |
| CHEMBL4750105 | — | — | 1 | 9.52 |
| CHEMBL4789383 | — | — | 1 | 9.26 |
| CHEMBL4065973 | — | — | 1 | 9.22 |
| CHEMBL4744011 | — | — | 1 | 9.00 |
| CHEMBL4753692 | — | — | 1 | 9.00 |
| CHEMBL4740668 | — | — | 1 | 9.00 |
| CHEMBL4759447 | — | — | 1 | 8.89 |
| CHEMBL4797426 | — | — | 1 | 8.85 |
| CHEMBL4758442 | — | — | 1 | 8.82 |
| CHEMBL4788623 | — | — | 1 | 8.77 |
| CHEMBL4775988 | — | — | 1 | 8.77 |
| CHEMBL4755954 | — | — | 1 | 8.77 |
| CHEMBL4799454 | — | — | 1 | 8.72 |
| CHEMBL4761000 | — | — | 1 | 8.72 |
| CHEMBL4745212 | — | — | 1 | 8.66 |
| CHEMBL4763310 | — | — | 1 | 8.62 |
| CHEMBL4744024 | — | — | 1 | 8.60 |
| CHEMBL4794535 | — | — | 1 | 8.52 |
| CHEMBL4741692 | — | — | 1 | 8.48 |
| CHEMBL4760648 | — | — | 1 | 8.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4787992 | — | IC50 | = | 0.05012 | nM | 10.30 |
| CHEMBL4751860 | — | IC50 | = | 0.1995 | nM | 9.70 |
| CHEMBL4764067 | — | IC50 | = | 0.2188 | nM | 9.66 |
| CHEMBL4786278 | — | IC50 | = | 0.2951 | nM | 9.53 |
| CHEMBL4795982 | — | IC50 | = | 0.302 | nM | 9.52 |
| CHEMBL4750105 | — | IC50 | = | 0.302 | nM | 9.52 |
| CHEMBL4789383 | — | IC50 | = | 0.5495 | nM | 9.26 |
| CHEMBL4065973 | — | IC50 | = | 0.6026 | nM | 9.22 |
| CHEMBL4744011 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4753692 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4740668 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4759447 | — | IC50 | = | 1.288 | nM | 8.89 |
| CHEMBL4797426 | — | IC50 | = | 1.413 | nM | 8.85 |
| CHEMBL4758442 | — | IC50 | = | 1.514 | nM | 8.82 |
| CHEMBL4788623 | — | IC50 | = | 1.698 | nM | 8.77 |
| CHEMBL4775988 | — | IC50 | = | 1.698 | nM | 8.77 |
| CHEMBL4755954 | — | IC50 | = | 1.698 | nM | 8.77 |
| CHEMBL4799454 | — | IC50 | = | 1.905 | nM | 8.72 |
| CHEMBL4761000 | — | IC50 | = | 1.905 | nM | 8.72 |
| CHEMBL4745212 | — | IC50 | = | 2.188 | nM | 8.66 |
| CHEMBL4763310 | — | IC50 | = | 2.399 | nM | 8.62 |
| CHEMBL4744024 | — | IC50 | = | 2.512 | nM | 8.60 |
| CHEMBL4794535 | — | IC50 | = | 3.02 | nM | 8.52 |
| CHEMBL4741692 | — | IC50 | = | 3.311 | nM | 8.48 |
| CHEMBL4760648 | — | IC50 | = | 6.31 | nM | 8.20 |