Assay Detail
Binding
CHEMBL4709840
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]spiperone from D2 receptor in rat striatum measured after 15 mins by liquid scintillation counting method
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Isoquinolinone derivatives as potent CNS multi-receptor D/5-HT/5-HT/5-HT/5-HT agents: Synthesis and pharmacological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 32 | 6.79 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 8.43 |
| CHEMBL4764679 | — | — | 1 | 8.16 |
| CHEMBL4743324 | — | — | 1 | 8.04 |
| CHEMBL1112 | ARIPIPRAZOLE | 4.0 | 1 | 8.01 |
| CHEMBL3965773 | — | — | 1 | 7.53 |
| CHEMBL4783375 | — | — | 1 | 7.38 |
| CHEMBL4749019 | — | — | 1 | 7.17 |
| CHEMBL4777373 | — | — | 1 | 6.93 |
| CHEMBL4779075 | — | — | 1 | 6.91 |
| CHEMBL3911283 | — | — | 1 | 6.79 |
| CHEMBL4746373 | — | — | 1 | 6.60 |
| CHEMBL4781390 | — | — | 1 | 6.58 |
| CHEMBL4749033 | — | — | 1 | 6.57 |
| CHEMBL4759887 | — | — | 1 | 6.50 |
| CHEMBL4790565 | — | — | 1 | 6.45 |
| CHEMBL4753384 | — | — | 1 | 6.41 |
| CHEMBL4778204 | — | — | 1 | 6.27 |
| CHEMBL4742251 | — | — | 1 | 6.25 |
| CHEMBL4797306 | — | — | 1 | 6.16 |
| CHEMBL4788000 | — | — | 1 | 6.05 |
| CHEMBL4741087 | — | — | 1 | 6.04 |
| CHEMBL4754923 | — | — | 1 | 6.04 |
| CHEMBL4795213 | — | — | 1 | 5.91 |
| CHEMBL4761213 | — | — | 1 | 5.86 |
| CHEMBL4758213 | — | — | 1 | - |
| CHEMBL4761618 | — | — | 1 | - |
| CHEMBL4800484 | — | — | 1 | - |
| CHEMBL4798115 | — | — | 1 | - |
| CHEMBL4756417 | — | — | 1 | - |
| CHEMBL4795287 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL85 | RISPERIDONE | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL4764679 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL4743324 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL1112 | ARIPIPRAZOLE | Ki | = | 9.7 | nM | 8.01 |
| CHEMBL3965773 | — | Ki | = | 29.3 | nM | 7.53 |
| CHEMBL4783375 | — | Ki | = | 41.6 | nM | 7.38 |
| CHEMBL4749019 | — | Ki | = | 68.2 | nM | 7.17 |
| CHEMBL4777373 | — | Ki | = | 117.2 | nM | 6.93 |
| CHEMBL4779075 | — | Ki | = | 123.2 | nM | 6.91 |
| CHEMBL3911283 | — | Ki | = | 161.9 | nM | 6.79 |
| CHEMBL4746373 | — | Ki | = | 249.2 | nM | 6.60 |
| CHEMBL4781390 | — | Ki | = | 261.4 | nM | 6.58 |
| CHEMBL4749033 | — | Ki | = | 268.3 | nM | 6.57 |
| CHEMBL4759887 | — | Ki | = | 316.3 | nM | 6.50 |
| CHEMBL4790565 | — | Ki | = | 359.2 | nM | 6.45 |
| CHEMBL4753384 | — | Ki | = | 391.2 | nM | 6.41 |
| CHEMBL4778204 | — | Ki | = | 532.4 | nM | 6.27 |
| CHEMBL4742251 | — | Ki | = | 568.2 | nM | 6.25 |
| CHEMBL4797306 | — | Ki | = | 698.0 | nM | 6.16 |
| CHEMBL4788000 | — | Ki | = | 896.0 | nM | 6.05 |
| CHEMBL4741087 | — | Ki | = | 923.0 | nM | 6.04 |
| CHEMBL4754923 | — | Ki | = | 902.0 | nM | 6.04 |
| CHEMBL4795213 | — | Ki | = | 1237.0 | nM | 5.91 |
| CHEMBL4761213 | — | Ki | = | 1368.0 | nM | 5.86 |
| CHEMBL4758213 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4761618 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4800484 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4798115 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4756417 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4795287 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4751120 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4743127 | — | Ki | > | 10000.0 | nM | - |