Assay Detail
Binding
CHEMBL4714263
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BTK (unknown origin) One-hour enzymatic assay without pre-incubation
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Small molecule approaches to treat autoimmune and inflammatory diseases (Part I): Kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.74 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1873475 | IBRUTINIB | 4.0 | 1 | 9.30 |
| CHEMBL4560385 | — | — | 1 | 9.30 |
| CHEMBL3702854 | RILZABRUTINIB | 3.0 | 1 | 8.89 |
| CHEMBL4163691 | POSELTINIB | 2.0 | 1 | 8.71 |
| CHEMBL4594348 | ELSUBRUTINIB | 2.0 | 1 | 7.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1873475 | IBRUTINIB | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4560385 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL3702854 | RILZABRUTINIB | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4163691 | POSELTINIB | IC50 | = | 1.95 | nM | 8.71 |
| CHEMBL4594348 | ELSUBRUTINIB | IC50 | = | 33.0 | nM | 7.48 |