Compound Detail
CHEMBL4594348
ELSUBRUTINIB 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL4594348 |
| Name | ELSUBRUTINIB |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | UNHZLHSLZZWMNP-LLVKDONJSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
3
Known Names
2
Indications
1
Mechanisms
Molecular Properties
297.4
MW (Da)
2.16
ALogP
2
HBA
2
HBD
79.2
PSA (Ų)
0.85
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Tyrosine-protein kinase BTK inhibitor | INHIBITOR | Tyrosine-protein kinase BTK | ✓ | ✓ |
Indications
Arthritis, Rheumatoid Lupus Erythematosus, Systemic
Activity Summary
IC50 1 meas. best 7.48
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase BTK CHEMBL5251 | IC50 | 7.48 | 7.48 | 33.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase BTK | IC50 | = | 33.0 | nM | 7.48 | Inhibition of BTK (unknown origin) One-hour enzymatic assay without pre-incubati... | 33609659 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33609659 | 10.1016/j.bmcl.2021.127862 | Tyrosine-protein kinase BTK | 1 |
Data from ChEMBL 36 via Core Engine