Assay Detail
Functional
CHEMBL4714603
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Antiproliferative activity against human IGROV1 cells assessed as reduction in cell viability after 96 hrs by CellTiter-blue assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | IGROV-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.52 | 8.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL491104 | — | — | 1 | 8.23 |
| CHEMBL4741259 | — | — | 1 | 7.99 |
| CHEMBL4761741 | — | — | 1 | 7.59 |
| CHEMBL4790375 | — | — | 1 | 7.27 |
| CHEMBL4759798 | — | — | 1 | 7.06 |
| CHEMBL4755197 | — | — | 1 | 6.97 |
| CHEMBL4783397 | — | — | 1 | - |
| CHEMBL4789686 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL491104 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL4741259 | — | IC50 | = | 10.14 | nM | 7.99 |
| CHEMBL4761741 | — | IC50 | = | 25.97 | nM | 7.59 |
| CHEMBL4790375 | — | IC50 | = | 54.13 | nM | 7.27 |
| CHEMBL4759798 | — | IC50 | = | 86.7 | nM | 7.06 |
| CHEMBL4755197 | — | IC50 | = | 108.21 | nM | 6.97 |
| CHEMBL4783397 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4789686 | — | IC50 | > | 1000.0 | nM | - |