Assay Detail
Binding
CHEMBL4715098
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Inhibition of recombinant ovine COX1
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of Fluorescence Imaging Probes for Labeling COX-1 in Live Ovarian Cancer Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.22 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26915 | SC-560 | — | 1 | 8.00 |
| CHEMBL4800072 | — | — | 1 | 7.00 |
| CHEMBL4784073 | — | — | 1 | 6.72 |
| CHEMBL4797035 | — | — | 1 | 6.60 |
| CHEMBL4758829 | — | — | 1 | 6.08 |
| CHEMBL4755592 | — | — | 1 | 5.92 |
| CHEMBL4745938 | — | — | 1 | 5.80 |
| CHEMBL4788232 | — | — | 1 | 5.58 |
| CHEMBL4761793 | — | — | 1 | 5.47 |
| CHEMBL4757602 | — | — | 1 | 5.07 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26915 | SC-560 | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4800072 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4784073 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4797035 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4758829 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL4755592 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4745938 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4788232 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4761793 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4757602 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL118 | CELECOXIB | IC50 | > | 100000.0 | nM | - |