Assay Detail
Binding
CHEMBL4716041
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]NMS from human recombinant muscarinic receptor M1 expressed in CHO-K9 cell membranes measured after 3 hrs by radioligand competition binding assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K9 |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Differently fluorescence-labelled dibenzodiazepinone-type muscarinic acetylcholine receptor ligands with high M2R affinity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.69 | 10.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4634333 | — | — | 1 | 10.50 |
| CHEMBL4794548 | — | — | 1 | 9.30 |
| CHEMBL4742721 | — | — | 1 | 9.00 |
| CHEMBL4756833 | — | — | 1 | 8.59 |
| CHEMBL4748004 | — | — | 1 | 8.32 |
| CHEMBL4754371 | — | — | 1 | 8.31 |
| CHEMBL4789147 | — | — | 1 | 8.21 |
| CHEMBL4744233 | — | — | 1 | 8.15 |
| CHEMBL4650998 | — | — | 1 | 7.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4634333 | — | Ki | = | 0.03162 | nM | 10.50 |
| CHEMBL4794548 | — | Ki | = | 0.5012 | nM | 9.30 |
| CHEMBL4742721 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL4756833 | — | Ki | = | 2.57 | nM | 8.59 |
| CHEMBL4748004 | — | Ki | = | 4.786 | nM | 8.32 |
| CHEMBL4754371 | — | Ki | = | 4.898 | nM | 8.31 |
| CHEMBL4789147 | — | Ki | = | 6.166 | nM | 8.21 |
| CHEMBL4744233 | — | Ki | = | 7.079 | nM | 8.15 |
| CHEMBL4650998 | — | Ki | = | 13.8 | nM | 7.86 |