Assay Detail
Binding
CHEMBL4716042
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K9 cell membranes measured after 3 hrs by radioligand competition binding assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K9 |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Differently fluorescence-labelled dibenzodiazepinone-type muscarinic acetylcholine receptor ligands with high M2R affinity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 9.15 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4634333 | — | — | 1 | 10.40 |
| CHEMBL4756833 | — | — | 1 | 9.62 |
| CHEMBL4636083 | — | — | 1 | 9.25 |
| CHEMBL4645845 | — | — | 1 | 9.23 |
| CHEMBL4742721 | — | — | 1 | 9.16 |
| CHEMBL4754371 | — | — | 1 | 9.04 |
| CHEMBL4748004 | — | — | 1 | 9.02 |
| CHEMBL4744233 | — | — | 1 | 8.87 |
| CHEMBL4794548 | — | — | 1 | 8.80 |
| CHEMBL4789147 | — | — | 1 | 8.75 |
| CHEMBL4650998 | — | — | 1 | 8.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4634333 | — | Ki | = | 0.03981 | nM | 10.40 |
| CHEMBL4756833 | — | Ki | = | 0.2399 | nM | 9.62 |
| CHEMBL4636083 | — | Ki | = | 0.5623 | nM | 9.25 |
| CHEMBL4645845 | — | Ki | = | 0.5888 | nM | 9.23 |
| CHEMBL4742721 | — | Ki | = | 0.6918 | nM | 9.16 |
| CHEMBL4754371 | — | Ki | = | 0.912 | nM | 9.04 |
| CHEMBL4748004 | — | Ki | = | 0.955 | nM | 9.02 |
| CHEMBL4744233 | — | Ki | = | 1.349 | nM | 8.87 |
| CHEMBL4794548 | — | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL4789147 | — | Ki | = | 1.778 | nM | 8.75 |
| CHEMBL4650998 | — | Ki | = | 3.02 | nM | 8.52 |