Assay Detail
ADMET
CHEMBL4716865
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP3A4 (unknown origin) using midazolam as substrate
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of novel selective anaplastic lymphoma kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.39 | 5.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4798141 | — | — | 1 | 5.48 |
| CHEMBL4762256 | — | — | 1 | 5.35 |
| CHEMBL4779222 | — | — | 1 | 5.34 |
| CHEMBL3651854 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4798141 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4762256 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4779222 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL3651854 | — | IC50 | > | 25000.0 | nM | - |