Assay Detail
ADMET
CHEMBL4716896
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against differentiated human THP-1 cells measured after 48 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of 1,3,6-trisubstituted β-carboline derivatives for cytotoxic and anti-leishmanial potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.37 | 4.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4783669 | — | — | 1 | 4.50 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 4.50 |
| CHEMBL4750583 | — | — | 1 | 4.11 |
| CHEMBL1209196 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4783669 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL125 | MILTEFOSINE | IC50 | = | 31500.0 | nM | 4.50 |
| CHEMBL4750583 | — | IC50 | = | 77000.0 | nM | 4.11 |
| CHEMBL1209196 | — | IC50 | > | 100000.0 | nM | - |