Assay Detail
ADMET
CHEMBL4717168
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Inhibition of Ovine COX-1 assessed as decrease in prostaglandin production using arachidonic acid as substrate pretreated for 15 mins followed by substrate addition and measured after 2 mins by enzyme immunoassay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Cyclooxygenase-2 and 15-lipoxygenase inhibition, synthesis, anti-inflammatory activity and ulcer liability of new celecoxib analogues: Determination of region-specific pyrazole ring formation by NOESY.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.26 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25 | ASPIRIN | 4.0 | 1 | 6.52 |
| CHEMBL4750876 | — | — | 1 | 5.41 |
| CHEMBL4778023 | — | — | 1 | 5.24 |
| CHEMBL4785437 | — | — | 1 | 5.19 |
| CHEMBL4787167 | — | — | 1 | 5.19 |
| CHEMBL4789752 | — | — | 1 | 5.17 |
| CHEMBL4798825 | — | — | 1 | 5.17 |
| CHEMBL4746534 | — | — | 1 | 5.14 |
| CHEMBL4789069 | — | — | 1 | 5.12 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 5.12 |
| CHEMBL4764063 | — | — | 1 | 5.08 |
| CHEMBL4765087 | — | — | 1 | 5.07 |
| CHEMBL4764950 | — | — | 1 | 4.99 |
| CHEMBL1562610 | MECLOFENAMATE SODIUM | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25 | ASPIRIN | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4750876 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4778023 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL4785437 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL4787167 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL4789752 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL4798825 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL4746534 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL4789069 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL118 | CELECOXIB | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL4764063 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL4765087 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL4764950 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL1562610 | MECLOFENAMATE SODIUM | IC50 | - | — | - |