Assay Detail
Binding
CHEMBL4719633
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of STING in mouse RAW-Lucia ISG cells assessed as induction of type I IFNs stimulation by measuring induction of IRF pathway incubated for 48 hrs by luciferase reporter gene assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | RAW |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Stimulator of interferon genes protein (CHEMBL4523311) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Design, Synthesis, and Biological Evaluation of Novel Cyclic Adenosine-Inosine Monophosphate (cAIMP) Analogs That Activate Stimulator of Interferon Genes (STING).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 5.14 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4751982 | — | — | 1 | 6.22 |
| CHEMBL4752156 | — | — | 1 | 5.66 |
| CHEMBL4762242 | — | — | 1 | 5.40 |
| CHEMBL4800420 | — | — | 1 | 5.30 |
| CHEMBL4797965 | — | — | 1 | 5.29 |
| CHEMBL4552089 | — | — | 1 | 5.21 |
| CHEMBL4776666 | — | — | 1 | 5.08 |
| CHEMBL4753213 | — | — | 1 | 5.04 |
| CHEMBL4783642 | — | — | 1 | 4.94 |
| CHEMBL4797172 | — | — | 1 | 4.80 |
| CHEMBL4761077 | — | — | 1 | 4.76 |
| CHEMBL4465054 | — | — | 1 | 4.73 |
| CHEMBL71263 | VADIMEZAN | 3.0 | 1 | 4.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4751982 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4752156 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4762242 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4800420 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4797965 | — | EC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4552089 | — | EC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL4776666 | — | EC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL4753213 | — | EC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL4783642 | — | EC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL4797172 | — | EC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL4761077 | — | EC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL4465054 | — | EC50 | = | 18800.0 | nM | 4.73 |
| CHEMBL71263 | VADIMEZAN | EC50 | = | 35200.0 | nM | 4.45 |