Compound Detail

CHEMBL4797172

Enter ChEMBL ID:

Free Research Context This compound will appear in recent viewed items on the research home for this browser.

Nc1ncnc2c1ncn2[C@@H]1O[C@@H]2COP(=O)(O)O[C@H]3[C@@H](O)[C@H](n4cnc5c(O)ncnc54)O[C@@H]3COP(=O)(O)O[C@@H]1[C@@H]2O

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL4797172
Phase	Preclinical
Structure Type	MOL
InChI Key	MULGIEVPXCNQLQ-XPWFQUROSA-N

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

659.4

MW (Da)

-1.51

ALogP

HBA

HBD

303.9

PSA (Å²)

0.13

QED

Ro5 Violations

Rot. Bonds

First in Class Prodrug

EC50 4 meas. best 4.95

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Stimulator of interferon genes protein CHEMBL4523377	EC50	4.95	4.6633	11200.0	3
Stimulator of interferon genes protein CHEMBL4523311	EC50	4.8	4.8	15900.0	1

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Stimulator of interferon genes protein	EC50	=	11200.0	nM	4.95	Activation of STING in human blood assessed as induction of type I IFNs incubate...	27783523
Stimulator of interferon genes protein	EC50	=	15100.0	nM	4.82	Activation of STING in human THP-1-Dual cells assessed as induction of type I IF...	27783523
Stimulator of interferon genes protein	EC50	=	15900.0	nM	4.8	Activation of STING in mouse RAW-Lucia ISG cells assessed as induction of type I...	27783523
Stimulator of interferon genes protein	EC50	=	60600.0	nM	4.22	Activation of STING in human THP-1-Dual cells assessed as induction of type I IF...	27783523

PubMed	DOI	Target Context	# Activities
27783523	10.1021/acs.jmedchem.6b01300	Stimulator of interferon genes protein	8
27783523	10.1021/acs.jmedchem.6b01300	Unchecked	1

Data from ChEMBL 36 via Core Engine