Assay Detail
Binding
CHEMBL4719637
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of STING in human THP-1-Dual cells assessed as induction of type I IFNs by measuring stimulation of NF-kappaB pathway incubated for 48 hrs by luciferase reporter gene assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Stimulator of interferon genes protein (CHEMBL4523377) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, Synthesis, and Biological Evaluation of Novel Cyclic Adenosine-Inosine Monophosphate (cAIMP) Analogs That Activate Stimulator of Interferon Genes (STING).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 4.70 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4751982 | — | — | 1 | 5.80 |
| CHEMBL4762242 | — | — | 1 | 5.11 |
| CHEMBL4752156 | — | — | 1 | 5.00 |
| CHEMBL4797965 | — | — | 1 | 4.81 |
| CHEMBL4776666 | — | — | 1 | 4.80 |
| CHEMBL4753213 | — | — | 1 | 4.59 |
| CHEMBL4800420 | — | — | 1 | 4.49 |
| CHEMBL4465054 | — | — | 1 | 4.41 |
| CHEMBL4552089 | — | — | 1 | 4.26 |
| CHEMBL4797172 | — | — | 1 | 4.22 |
| CHEMBL4783642 | — | — | 1 | 4.21 |
| CHEMBL4761077 | — | — | 1 | - |
| CHEMBL71263 | VADIMEZAN | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4751982 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4762242 | — | EC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL4752156 | — | EC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL4797965 | — | EC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL4776666 | — | EC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL4753213 | — | EC50 | = | 25500.0 | nM | 4.59 |
| CHEMBL4800420 | — | EC50 | = | 32300.0 | nM | 4.49 |
| CHEMBL4465054 | — | EC50 | = | 39100.0 | nM | 4.41 |
| CHEMBL4552089 | — | EC50 | = | 54300.0 | nM | 4.26 |
| CHEMBL4797172 | — | EC50 | = | 60600.0 | nM | 4.22 |
| CHEMBL4783642 | — | EC50 | = | 62300.0 | nM | 4.21 |
| CHEMBL4761077 | — | EC50 | = | 110900.0 | nM | - |
| CHEMBL71263 | VADIMEZAN | EC50 | - | — | - |