Assay Detail
Binding
CHEMBL4723101
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Inhibition of human His-tagged tyrosinase expressed in HEK 293 cells using L-DOPA as substrate by MBTH based assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Advances in the Design of Genuine Human Tyrosinase Inhibitors for Targeting Melanogenesis and Related Pigmentations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.89 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4743159 | — | — | 1 | 5.96 |
| CHEMBL450195 | RUCINOL | — | 1 | 4.68 |
| CHEMBL443605 | HEXYLRESORCINOL | -1.0 | 1 | 4.03 |
| CHEMBL537 | HYDROQUINONE | 4.0 | 1 | - |
| CHEMBL287556 | KOJIC ACID | — | 1 | - |
| CHEMBL3961037 | — | — | 1 | - |
| CHEMBL232202 | ARBUTIN | 2.0 | 1 | - |
| CHEMBL24147 | RESORCINOL | -1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4743159 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL450195 | RUCINOL | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL443605 | HEXYLRESORCINOL | IC50 | = | 94000.0 | nM | 4.03 |
| CHEMBL537 | HYDROQUINONE | IC50 | = | 4400000.0 | nM | - |
| CHEMBL287556 | KOJIC ACID | IC50 | = | 500000.0 | nM | - |
| CHEMBL3961037 | — | IC50 | = | 131000.0 | nM | - |
| CHEMBL232202 | ARBUTIN | IC50 | = | 6500000.0 | nM | - |
| CHEMBL24147 | RESORCINOL | IC50 | > | 3000000.0 | nM | - |