Assay Detail
Binding
CHEMBL4723114
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Inhibition of human tyrosinase using L- DOPA as substrate by MBTH based assay
15
Total Activities
15
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Advances in the Design of Genuine Human Tyrosinase Inhibitors for Targeting Melanogenesis and Related Pigmentations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.43 | 5.85 |
| Ki | 7 | 4.34 | 4.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4763438 | — | — | 1 | 5.85 |
| CHEMBL4792744 | — | — | 1 | 5.80 |
| CHEMBL4795966 | — | — | 1 | 5.60 |
| CHEMBL590969 | — | — | 1 | 5.58 |
| CHEMBL4782537 | — | — | 1 | 5.50 |
| CHEMBL1491393 | — | — | 1 | 5.50 |
| CHEMBL4757374 | — | — | 1 | 5.34 |
| CHEMBL1269349 | — | — | 1 | 4.72 |
| CHEMBL1269350 | — | — | 1 | 4.57 |
| CHEMBL4751526 | — | — | 1 | 4.34 |
| CHEMBL1269399 | — | — | 1 | 4.34 |
| CHEMBL4746238 | — | — | 1 | 4.30 |
| CHEMBL541251 | — | — | 1 | 4.29 |
| CHEMBL4794995 | — | — | 1 | 4.12 |
| CHEMBL4777553 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4763438 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4792744 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4795966 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL590969 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4782537 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL1491393 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4757374 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL1269349 | — | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL1269350 | — | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL4751526 | — | Ki | = | 46000.0 | nM | 4.34 |
| CHEMBL1269399 | — | Ki | = | 46000.0 | nM | 4.34 |
| CHEMBL4746238 | — | Ki | = | 50000.0 | nM | 4.30 |
| CHEMBL541251 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL4794995 | — | Ki | = | 75000.0 | nM | 4.12 |
| CHEMBL4777553 | — | Ki | = | 100000.0 | nM | 4.00 |