Assay Detail
Binding
CHEMBL4723516
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to sigma-1 receptor (unknown origin)
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL287) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Small Molecules Selectively Targeting Sigma-1 Receptor for the Treatment of Neurological Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.78 | 8.19 |
| IC50 | 1 | 6.07 | 6.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.19 |
| CHEMBL4777306 | — | — | 1 | 8.10 |
| CHEMBL100116 | PENTAZOCINE | 4.0 | 1 | 7.92 |
| CHEMBL73234 | CARBETAPENTANE | 4.0 | 1 | 6.89 |
| CHEMBL4297224 | BLARCAMESINE | 3.0 | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL4777306 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL100116 | PENTAZOCINE | Ki | = | 12.1 | nM | 7.92 |
| CHEMBL73234 | CARBETAPENTANE | Ki | = | 129.0 | nM | 6.89 |
| CHEMBL4297224 | BLARCAMESINE | IC50 | = | 860.0 | nM | 6.07 |