Assay Detail
Binding
CHEMBL4723541
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in rat liver membranes incubated for 60 mins in presence of [3H]DTG by radioactivity method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL3602) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Small Molecules Selectively Targeting Sigma-1 Receptor for the Treatment of Neurological Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.87 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39900 | SPIPETHIANE | — | 1 | 9.30 |
| CHEMBL4796879 | — | — | 1 | 8.85 |
| CHEMBL4763051 | — | — | 1 | 8.85 |
| CHEMBL4744344 | — | — | 1 | 8.84 |
| CHEMBL4760729 | — | — | 1 | 8.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39900 | SPIPETHIANE | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL4796879 | — | Ki | = | 1.41 | nM | 8.85 |
| CHEMBL4763051 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL4744344 | — | Ki | = | 1.45 | nM | 8.84 |
| CHEMBL4760729 | — | Ki | = | 2.95 | nM | 8.53 |