Assay Detail
ADMET
CHEMBL4723654
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Inhibition of CYP3A4 (unknown origin)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of new bivalent quinazoline analogues as IAP antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.94 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4789776 | — | — | 1 | 6.62 |
| CHEMBL4760660 | — | — | 1 | 6.37 |
| CHEMBL4788002 | — | — | 1 | 6.34 |
| CHEMBL4758649 | — | — | 1 | 6.18 |
| CHEMBL4739976 | — | — | 1 | 6.07 |
| CHEMBL4753756 | — | — | 1 | 5.45 |
| CHEMBL4750995 | — | — | 1 | 5.26 |
| CHEMBL4795924 | — | — | 1 | 5.25 |
| CHEMBL4781806 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4789776 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4760660 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4788002 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4758649 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL4739976 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL4753756 | — | IC50 | = | 3560.0 | nM | 5.45 |
| CHEMBL4750995 | — | IC50 | = | 5530.0 | nM | 5.26 |
| CHEMBL4795924 | — | IC50 | = | 5650.0 | nM | 5.25 |
| CHEMBL4781806 | — | IC50 | < | 620.0 | nM | - |