Assay Detail
Binding
CHEMBL4724360
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Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition and measured after 2 mins by Ellman's method
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Tissue | Serum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel BuChE-IDO1 inhibitors from sertaconazole: Virtual screening, chemical optimization and molecular modeling studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.30 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4782213 | — | — | 1 | 7.05 |
| CHEMBL4785129 | — | — | 1 | 6.00 |
| CHEMBL4740576 | — | — | 1 | 5.96 |
| CHEMBL4757927 | — | — | 1 | 5.85 |
| CHEMBL4776465 | — | — | 1 | 5.41 |
| CHEMBL4744876 | — | — | 1 | 5.41 |
| CHEMBL4778194 | — | — | 1 | 5.40 |
| CHEMBL91 | MICONAZOLE | 4.0 | 1 | 5.37 |
| CHEMBL4749685 | — | — | 1 | 5.24 |
| CHEMBL4740250 | — | — | 1 | 5.22 |
| CHEMBL4759974 | — | — | 1 | 5.21 |
| CHEMBL1201196 | SERTACONAZOLE | 4.0 | 1 | 5.13 |
| CHEMBL4782238 | — | — | 1 | 5.10 |
| CHEMBL4741786 | — | — | 1 | 5.00 |
| CHEMBL4787968 | — | — | 1 | 4.95 |
| CHEMBL4792640 | — | — | 1 | 4.82 |
| CHEMBL4783412 | — | — | 1 | 4.75 |
| CHEMBL4747120 | — | — | 1 | 4.50 |
| CHEMBL3318359 | — | — | 1 | 4.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4782213 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4785129 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4740576 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4757927 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4776465 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4744876 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4778194 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL91 | MICONAZOLE | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4749685 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4740250 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4759974 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL1201196 | SERTACONAZOLE | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL4782238 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL4741786 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4787968 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL4792640 | — | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL4783412 | — | IC50 | = | 17600.0 | nM | 4.75 |
| CHEMBL4747120 | — | IC50 | = | 31900.0 | nM | 4.50 |
| CHEMBL3318359 | — | IC50 | = | 41700.0 | nM | 4.38 |