Assay Detail
ADMET
CHEMBL4725979
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Inhibition of recombinant human CYP3A4
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of BMS-986235/LAR-1219: A Potent Formyl Peptide Receptor 2 (FPR2) Selective Agonist for the Prevention of Heart Failure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.25 | 5.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4760897 | — | — | 1 | 5.25 |
| CHEMBL4781596 | — | — | 1 | - |
| CHEMBL4784510 | BMS-986235 | 1.0 | 1 | - |
| CHEMBL4762030 | — | — | 1 | - |
| CHEMBL4790836 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4760897 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL4781596 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4784510 | BMS-986235 | IC50 | > | 20000.0 | nM | - |
| CHEMBL4762030 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4790836 | — | IC50 | > | 20000.0 | nM | - |