Assay Detail
Binding
CHEMBL4727430
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Inhibition of TEC (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent, non-covalent reversible BTK inhibitors with 8-amino-imidazo[1,5-a]pyrazine core featuring 3-position bicyclic ring substitutes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.11 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4108687 | — | — | 1 | 7.57 |
| CHEMBL4106978 | — | — | 1 | 7.20 |
| CHEMBL4114929 | — | — | 1 | 7.17 |
| CHEMBL4749037 | — | — | 1 | 7.04 |
| CHEMBL4107779 | — | — | 1 | 6.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4108687 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4106978 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL4114929 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL4749037 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL4107779 | — | IC50 | = | 277.0 | nM | 6.56 |