Assay Detail
Binding
CHEMBL4728931
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Binding affinity to c-Kit (unknown origin) by kinome scan assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mast/stem cell growth factor receptor Kit (CHEMBL1936) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of IACS-9439, a Potent, Exquisitely Selective, and Orally Bioavailable Inhibitor of CSF1R.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 18 | 6.01 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4741283 | — | — | 1 | 7.36 |
| CHEMBL4788945 | — | — | 1 | 7.10 |
| CHEMBL4798876 | — | — | 1 | 6.77 |
| CHEMBL4759047 | — | — | 1 | 6.75 |
| CHEMBL4798601 | — | — | 1 | 6.28 |
| CHEMBL4795462 | — | — | 1 | 6.10 |
| CHEMBL4756510 | — | — | 1 | 6.00 |
| CHEMBL4763875 | — | — | 1 | 5.68 |
| CHEMBL4227505 | SOTULETINIB | 2.0 | 1 | 5.52 |
| CHEMBL4788832 | — | — | 1 | 5.32 |
| CHEMBL4748740 | — | — | 1 | 4.77 |
| CHEMBL4746711 | — | — | 1 | 4.52 |
| CHEMBL4779878 | — | — | 1 | - |
| CHEMBL4798920 | — | — | 1 | - |
| CHEMBL4764974 | — | — | 1 | - |
| CHEMBL4777344 | — | — | 1 | - |
| CHEMBL4762843 | — | — | 1 | - |
| CHEMBL4751287 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4741283 | — | Kd | = | 44.0 | nM | 7.36 |
| CHEMBL4788945 | — | Kd | = | 79.0 | nM | 7.10 |
| CHEMBL4798876 | — | Kd | = | 170.0 | nM | 6.77 |
| CHEMBL4759047 | — | Kd | = | 180.0 | nM | 6.75 |
| CHEMBL4798601 | — | Kd | = | 530.0 | nM | 6.28 |
| CHEMBL4795462 | — | Kd | = | 790.0 | nM | 6.10 |
| CHEMBL4756510 | — | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL4763875 | — | Kd | = | 2100.0 | nM | 5.68 |
| CHEMBL4227505 | SOTULETINIB | Kd | = | 3000.0 | nM | 5.52 |
| CHEMBL4788832 | — | Kd | = | 4800.0 | nM | 5.32 |
| CHEMBL4748740 | — | Kd | = | 17000.0 | nM | 4.77 |
| CHEMBL4746711 | — | Kd | = | 30000.0 | nM | 4.52 |
| CHEMBL4779878 | — | Kd | > | 30000.0 | nM | - |
| CHEMBL4798920 | — | Kd | - | — | - | |
| CHEMBL4764974 | — | Kd | - | — | - | |
| CHEMBL4777344 | — | Kd | - | — | - | |
| CHEMBL4762843 | — | Kd | > | 30000.0 | nM | - |
| CHEMBL4751287 | — | Kd | > | 30000.0 | nM | - |