Compound Detail
CHEMBL4764974
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Basic Information
| ChEMBL ID | CHEMBL4764974 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XRXJSWIYYPKVBL-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
373.9
MW (Da)
5.67
ALogP
5
HBA
1
HBD
47.0
PSA (Ų)
0.63
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Macrophage colony-stimulating factor 1 receptor CHEMBL1844 | IC50 | 7.52 | 7.52 | 30.0 | 1 |
| Macrophage colony-stimulating factor 1 receptor CHEMBL5570 | IC50 | 5.92 | 5.92 | 1204.0 | 1 |
| NSO CHEMBL615003 | IC50 | 4.82 | 4.82 | 14989.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Macrophage colony-stimulating factor 1 receptor | IC50 | = | 30.0 | nM | 7.52 | Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tag... | 32787110 |
| Macrophage colony-stimulating factor 1 receptor | IC50 | = | 1204.0 | nM | 5.92 | Inhibition of CSF1R in mouse NFS-60 cells assessed as reduction in CSF-induced c... | 32787110 |
| NSO | IC50 | = | 14989.0 | nM | 4.82 | Antiproliferation activity against mouse NSO cells assessed as reduction in cell... | 32787110 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32787110 | 10.1021/acs.jmedchem.0c00936 | Unchecked | 5 |
| 32787110 | 10.1021/acs.jmedchem.0c00936 | Macrophage colony-stimulating factor 1 receptor | 4 |
| 32787110 | 10.1021/acs.jmedchem.0c00936 | Platelet-derived growth factor receptor beta | 2 |
| 32787110 | 10.1021/acs.jmedchem.0c00936 | Receptor-type tyrosine-protein kinase FLT3 | 1 |
| 32787110 | 10.1021/acs.jmedchem.0c00936 | Mast/stem cell growth factor receptor Kit | 1 |
| 32787110 | 10.1021/acs.jmedchem.0c00936 | Platelet-derived growth factor receptor alpha | 1 |
| 32787110 | 10.1021/acs.jmedchem.0c00936 | NSO | 1 |
Data from ChEMBL 36 via Core Engine