Assay Detail
Binding
CHEMBL4728940
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Inhibition of CSF1R in mouse NFS-60 cells assessed as reduction in CSF-induced cell proliferation after 72 hrs by CellTiter-Glo assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | NFS-60 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Macrophage colony-stimulating factor 1 receptor (CHEMBL5570) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery of IACS-9439, a Potent, Exquisitely Selective, and Orally Bioavailable Inhibitor of CSF1R.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.78 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4758092 | — | — | 1 | 8.15 |
| CHEMBL4748740 | — | — | 1 | 8.15 |
| CHEMBL4740157 | — | — | 1 | 7.85 |
| CHEMBL4779197 | — | — | 1 | 7.58 |
| CHEMBL4763289 | — | — | 1 | 7.32 |
| CHEMBL4741283 | — | — | 1 | 7.30 |
| CHEMBL4779878 | — | — | 1 | 7.22 |
| CHEMBL4754431 | — | — | 1 | 7.09 |
| CHEMBL4798876 | — | — | 1 | 7.01 |
| CHEMBL4787609 | — | — | 1 | 6.98 |
| CHEMBL4798601 | — | — | 1 | 6.98 |
| CHEMBL4763875 | — | — | 1 | 6.90 |
| CHEMBL4759047 | — | — | 1 | 6.88 |
| CHEMBL4762843 | — | — | 1 | 6.75 |
| CHEMBL4756510 | — | — | 1 | 6.72 |
| CHEMBL4795462 | — | — | 1 | 6.71 |
| CHEMBL4788945 | — | — | 1 | 6.64 |
| CHEMBL4790139 | — | — | 1 | 6.57 |
| CHEMBL4751287 | — | — | 1 | 6.54 |
| CHEMBL4746711 | — | — | 1 | 6.46 |
| CHEMBL4788832 | — | — | 1 | 6.30 |
| CHEMBL4798920 | — | — | 1 | 6.03 |
| CHEMBL4764974 | — | — | 1 | 5.92 |
| CHEMBL4743008 | — | — | 1 | 5.88 |
| CHEMBL4751359 | — | — | 1 | 5.84 |
| CHEMBL4777344 | — | — | 1 | 5.64 |
| CHEMBL4783368 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4758092 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4748740 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4740157 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4779197 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4763289 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL4741283 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4779878 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4754431 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL4798876 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL4787609 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL4798601 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL4763875 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL4759047 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL4762843 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL4756510 | — | IC50 | = | 189.0 | nM | 6.72 |
| CHEMBL4795462 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL4788945 | — | IC50 | = | 228.0 | nM | 6.64 |
| CHEMBL4790139 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4751287 | — | IC50 | = | 288.0 | nM | 6.54 |
| CHEMBL4746711 | — | IC50 | = | 345.0 | nM | 6.46 |
| CHEMBL4788832 | — | IC50 | = | 504.0 | nM | 6.30 |
| CHEMBL4798920 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL4764974 | — | IC50 | = | 1204.0 | nM | 5.92 |
| CHEMBL4743008 | — | IC50 | = | 1304.0 | nM | 5.88 |
| CHEMBL4751359 | — | IC50 | = | 1455.0 | nM | 5.84 |
| CHEMBL4777344 | — | IC50 | = | 2269.0 | nM | 5.64 |
| CHEMBL4783368 | — | IC50 | = | 2511.0 | nM | 5.60 |