Assay Detail
Binding
CHEMBL4728938
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human wild type PDGFRalpha (V575 to D1002 residues) expressed in mammalian expression system by kinome scan assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Platelet-derived growth factor receptor alpha (CHEMBL2007) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of IACS-9439, a Potent, Exquisitely Selective, and Orally Bioavailable Inhibitor of CSF1R.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 18 | 6.73 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4741283 | — | — | 1 | 8.89 |
| CHEMBL4759047 | — | — | 1 | 7.92 |
| CHEMBL4798601 | — | — | 1 | 7.92 |
| CHEMBL4798876 | — | — | 1 | 7.55 |
| CHEMBL4795462 | — | — | 1 | 7.50 |
| CHEMBL4788945 | — | — | 1 | 7.34 |
| CHEMBL4756510 | — | — | 1 | 7.03 |
| CHEMBL4227505 | SOTULETINIB | 2.0 | 1 | 6.68 |
| CHEMBL4763875 | — | — | 1 | 6.43 |
| CHEMBL4748740 | — | — | 1 | 5.72 |
| CHEMBL4788832 | — | — | 1 | 5.39 |
| CHEMBL4779878 | — | — | 1 | 4.62 |
| CHEMBL4746711 | — | — | 1 | 4.52 |
| CHEMBL4751287 | — | — | 1 | - |
| CHEMBL4762843 | — | — | 1 | - |
| CHEMBL4777344 | — | — | 1 | - |
| CHEMBL4798920 | — | — | 1 | - |
| CHEMBL4764974 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4741283 | — | Kd | = | 1.3 | nM | 8.89 |
| CHEMBL4759047 | — | Kd | = | 12.0 | nM | 7.92 |
| CHEMBL4798601 | — | Kd | = | 12.0 | nM | 7.92 |
| CHEMBL4798876 | — | Kd | = | 28.0 | nM | 7.55 |
| CHEMBL4795462 | — | Kd | = | 32.0 | nM | 7.50 |
| CHEMBL4788945 | — | Kd | = | 46.0 | nM | 7.34 |
| CHEMBL4756510 | — | Kd | = | 94.0 | nM | 7.03 |
| CHEMBL4227505 | SOTULETINIB | Kd | = | 210.0 | nM | 6.68 |
| CHEMBL4763875 | — | Kd | = | 370.0 | nM | 6.43 |
| CHEMBL4748740 | — | Kd | = | 1900.0 | nM | 5.72 |
| CHEMBL4788832 | — | Kd | = | 4100.0 | nM | 5.39 |
| CHEMBL4779878 | — | Kd | = | 24000.0 | nM | 4.62 |
| CHEMBL4746711 | — | Kd | = | 30000.0 | nM | 4.52 |
| CHEMBL4751287 | — | Kd | > | 30000.0 | nM | - |
| CHEMBL4762843 | — | Kd | > | 30000.0 | nM | - |
| CHEMBL4777344 | — | Kd | - | — | - | |
| CHEMBL4798920 | — | Kd | - | — | - | |
| CHEMBL4764974 | — | Kd | - | — | - |