Assay Detail
Binding
CHEMBL4733094
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant PDE4B using cAMP as substrate incubated for 20 mins measured by Kinase Glo reagent based microplate reader assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3',5'-cyclic-AMP phosphodiesterase 4B (CHEMBL275) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
New imidazopyridines with phosphodiesterase 4 and 7 inhibitory activity and their efficacy in animal models of inflammatory and autoimmune diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 5.05 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL299650 | — | — | 1 | 7.38 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 5.95 |
| CHEMBL4762789 | — | — | 1 | 5.60 |
| CHEMBL4755919 | — | — | 1 | 5.55 |
| CHEMBL4755193 | — | — | 1 | 5.49 |
| CHEMBL4787162 | — | — | 1 | 5.46 |
| CHEMBL4784075 | — | — | 1 | 5.45 |
| CHEMBL4781101 | — | — | 1 | 5.27 |
| CHEMBL4786151 | — | — | 1 | 5.15 |
| CHEMBL4749066 | — | — | 1 | 5.08 |
| CHEMBL4781432 | — | — | 1 | 5.07 |
| CHEMBL4789451 | — | — | 1 | 5.06 |
| CHEMBL4793395 | — | — | 1 | 5.01 |
| CHEMBL4778175 | — | — | 1 | 4.90 |
| CHEMBL4799953 | — | — | 1 | 4.81 |
| CHEMBL4752376 | — | — | 1 | 4.77 |
| CHEMBL4764312 | — | — | 1 | 4.74 |
| CHEMBL4752998 | — | — | 1 | 4.74 |
| CHEMBL4786766 | — | — | 1 | 4.72 |
| CHEMBL4798623 | — | — | 1 | 4.70 |
| CHEMBL4740026 | — | — | 1 | 4.63 |
| CHEMBL4758935 | — | — | 1 | 4.54 |
| CHEMBL4798575 | — | — | 1 | 4.40 |
| CHEMBL4784713 | — | — | 1 | 4.38 |
| CHEMBL4748290 | — | — | 1 | 4.30 |
| CHEMBL4798942 | — | — | 1 | 4.22 |
| CHEMBL4799475 | — | — | 1 | - |
| CHEMBL4758688 | — | — | 1 | - |
| CHEMBL4756762 | — | — | 1 | - |
| CHEMBL4763886 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL299650 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL4762789 | — | IC50 | = | 2530.0 | nM | 5.60 |
| CHEMBL4755919 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4755193 | — | IC50 | = | 3250.0 | nM | 5.49 |
| CHEMBL4787162 | — | IC50 | = | 3480.0 | nM | 5.46 |
| CHEMBL4784075 | — | IC50 | = | 3530.0 | nM | 5.45 |
| CHEMBL4781101 | — | IC50 | = | 5410.0 | nM | 5.27 |
| CHEMBL4786151 | — | IC50 | = | 7090.0 | nM | 5.15 |
| CHEMBL4749066 | — | IC50 | = | 8340.0 | nM | 5.08 |
| CHEMBL4781432 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL4789451 | — | IC50 | = | 8660.0 | nM | 5.06 |
| CHEMBL4793395 | — | IC50 | = | 9770.0 | nM | 5.01 |
| CHEMBL4778175 | — | IC50 | = | 12590.0 | nM | 4.90 |
| CHEMBL4799953 | — | IC50 | = | 15620.0 | nM | 4.81 |
| CHEMBL4752376 | — | IC50 | = | 16940.0 | nM | 4.77 |
| CHEMBL4764312 | — | IC50 | = | 18140.0 | nM | 4.74 |
| CHEMBL4752998 | — | IC50 | = | 18030.0 | nM | 4.74 |
| CHEMBL4786766 | — | IC50 | = | 19020.0 | nM | 4.72 |
| CHEMBL4798623 | — | IC50 | = | 19920.0 | nM | 4.70 |
| CHEMBL4740026 | — | IC50 | = | 23160.0 | nM | 4.63 |
| CHEMBL4758935 | — | IC50 | = | 28990.0 | nM | 4.54 |
| CHEMBL4798575 | — | IC50 | = | 39930.0 | nM | 4.40 |
| CHEMBL4784713 | — | IC50 | = | 41520.0 | nM | 4.38 |
| CHEMBL4748290 | — | IC50 | = | 49720.0 | nM | 4.30 |
| CHEMBL4798942 | — | IC50 | = | 60050.0 | nM | 4.22 |
| CHEMBL4799475 | — | IC50 | = | 102360.0 | nM | - |
| CHEMBL4758688 | — | IC50 | = | 102630.0 | nM | - |
| CHEMBL4756762 | — | IC50 | = | 100370.0 | nM | - |
| CHEMBL4763886 | — | IC50 | > | 200000.0 | nM | - |