Compound Detail
CHEMBL4749066
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Basic Information
| ChEMBL ID | CHEMBL4749066 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AIQFHNQYZNRWNO-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
360.5
MW (Da)
5.49
ALogP
5
HBA
1
HBD
55.9
PSA (Ų)
0.42
QED
1
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.08
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4B CHEMBL275 | IC50 | 5.08 | 5.08 | 8340.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4B | IC50 | = | 8340.0 | nM | 5.08 | Inhibition of human recombinant PDE4B using cAMP as substrate incubated for 20 m... | 33022582 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33022582 | 10.1016/j.ejmech.2020.112854 | 3',5'-cyclic-AMP phosphodiesterase 4B | 1 |
| 33022582 | 10.1016/j.ejmech.2020.112854 | High affinity 3',5'-cyclic-AMP phosphodiesterase 7A | 1 |
Data from ChEMBL 36 via Core Engine