Assay Detail
ADMET
CHEMBL4733967
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Cytotoxicity against human BEAS-2B cells incubated for 48 hrs by CCK-8 assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | BEAS-2B |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of novel benzimidazole-derived neddylation inhibitors for suppressing tumor growth invitro and invivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.52 | 5.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1231160 | PEVONEDISTAT | 3.0 | 1 | 5.91 |
| CHEMBL4744561 | — | — | 1 | 4.42 |
| CHEMBL1014 | CANDESARTAN CILEXETIL | 4.0 | 1 | 4.10 |
| CHEMBL4788522 | — | — | 1 | 4.10 |
| CHEMBL4746177 | — | — | 1 | 4.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1231160 | PEVONEDISTAT | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL4744561 | — | IC50 | = | 37910.0 | nM | 4.42 |
| CHEMBL1014 | CANDESARTAN CILEXETIL | IC50 | = | 79760.0 | nM | 4.10 |
| CHEMBL4788522 | — | IC50 | = | 79350.0 | nM | 4.10 |
| CHEMBL4746177 | — | IC50 | = | 80840.0 | nM | 4.09 |