Assay Detail
Binding
CHEMBL4734042
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human CDC7/Dbf4 expressed in baculovirus infected Sf9 insect cells assessed as inhibition of fluorescein labelled substrate phosphorylation in presence of ATP measured after 60 mins by TR-FRET assay
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase) (CHEMBL2111377) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Targeting nuclear protein TDP-43 by cell division cycle kinase 7 inhibitors: A new therapeutic approach for amyotrophic lateral sclerosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 6.45 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4747601 | — | — | 1 | 7.10 |
| CHEMBL4083753 | — | — | 1 | 7.05 |
| CHEMBL4094018 | — | — | 1 | 6.89 |
| CHEMBL4798875 | — | — | 1 | 6.89 |
| CHEMBL4791355 | — | — | 1 | 6.85 |
| CHEMBL4754930 | — | — | 1 | 6.85 |
| CHEMBL4778242 | — | — | 1 | 6.85 |
| CHEMBL342925 | — | — | 1 | 6.77 |
| CHEMBL1402653 | — | — | 1 | 6.75 |
| CHEMBL4786570 | — | — | 1 | 6.72 |
| CHEMBL4753615 | — | — | 1 | 6.72 |
| CHEMBL4788849 | — | — | 1 | 6.72 |
| CHEMBL397434 | — | — | 1 | 6.70 |
| CHEMBL4740308 | — | — | 1 | 6.64 |
| CHEMBL4748528 | — | — | 1 | 6.62 |
| CHEMBL4776786 | — | — | 1 | 6.60 |
| CHEMBL4776788 | — | — | 1 | 6.57 |
| CHEMBL4744159 | — | — | 1 | 6.54 |
| CHEMBL4756665 | — | — | 1 | 6.52 |
| CHEMBL4745322 | — | — | 1 | 6.52 |
| CHEMBL4747259 | — | — | 1 | 6.52 |
| CHEMBL4787888 | — | — | 1 | 6.50 |
| CHEMBL4787327 | — | — | 1 | 6.47 |
| CHEMBL4746008 | — | — | 1 | 6.44 |
| CHEMBL4758430 | — | — | 1 | 6.44 |
| CHEMBL4747973 | — | — | 1 | 6.41 |
| CHEMBL4752489 | — | — | 1 | 6.41 |
| CHEMBL1600876 | — | — | 1 | 6.36 |
| CHEMBL4795521 | — | — | 1 | 6.33 |
| CHEMBL4752064 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4747601 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4083753 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4094018 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4798875 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4791355 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4754930 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4778242 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL342925 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1402653 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4753615 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4788849 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4786570 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL397434 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4740308 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4748528 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4776786 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4776788 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4744159 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4756665 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4747259 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4745322 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4787888 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4787327 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4746008 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4758430 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4747973 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4752489 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL1600876 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL4795521 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4752064 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL4789025 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL4760791 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL4750945 | — | IC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL4781617 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL1870315 | — | IC50 | = | 3060.0 | nM | 5.51 |
| CHEMBL1336029 | — | IC50 | = | 3110.0 | nM | 5.51 |
| CHEMBL1532238 | — | IC50 | = | 4150.0 | nM | 5.38 |