Compound Detail
CHEMBL4745322
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Basic Information
| ChEMBL ID | CHEMBL4745322 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NKCFNMFPDQVQIG-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
272.3
MW (Da)
2.14
ALogP
5
HBA
2
HBD
74.7
PSA (Ų)
0.56
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase) CHEMBL2111377 | IC50 | 6.52 | 6.52 | 300.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase) | IC50 | = | 300.0 | nM | 6.52 | Inhibition of recombinant human CDC7/Dbf4 expressed in baculovirus infected Sf9 ... | 33139113 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33139113 | 10.1016/j.ejmech.2020.112968 | CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase) | 1 |
Data from ChEMBL 36 via Core Engine