Assay Detail
Binding
CHEMBL4734808
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at TRPV1 in rat isolated mesenteric arteries assessed as vasorelaxation of phenylephrine-induced contraction
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Artery |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transient receptor potential cation channel subfamily V member 1 (CHEMBL5102) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Paracetamol analogues conjugated by FAAH induce TRPV1-mediated antinociception without causing acute liver toxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 8.38 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL123254 | — | — | 1 | 9.30 |
| CHEMBL472898 | — | — | 1 | 8.90 |
| CHEMBL4747170 | — | — | 1 | 8.50 |
| CHEMBL4778235 | — | — | 1 | 8.40 |
| CHEMBL472897 | — | — | 1 | 7.90 |
| CHEMBL39878 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL123254 | — | EC50 | = | 0.5012 | nM | 9.30 |
| CHEMBL472898 | — | EC50 | = | 1.259 | nM | 8.90 |
| CHEMBL4747170 | — | EC50 | = | 3.162 | nM | 8.50 |
| CHEMBL4778235 | — | EC50 | = | 3.981 | nM | 8.40 |
| CHEMBL472897 | — | EC50 | = | 12.59 | nM | 7.90 |
| CHEMBL39878 | — | EC50 | = | 50.12 | nM | 7.30 |