Compound Detail
CHEMBL4747170
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Basic Information
| ChEMBL ID | CHEMBL4747170 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HEIGZRMXMDQRNO-ZKWNWVNESA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
425.6
MW (Da)
7.49
ALogP
3
HBA
2
HBD
58.6
PSA (Ų)
0.21
QED
1
Ro5 Violations
16
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 8.5
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 1 CHEMBL5102 | EC50 | 8.5 | 7.85 | 3.2 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 1 | EC50 | = | 3.162 | nM | 8.5 | Agonist activity at TRPV1 in rat isolated mesenteric arteries assessed as vasore... | 33257173 |
| Transient receptor potential cation channel subfamily V member 1 | EC50 | = | 63.1 | nM | 7.2 | Agonist activity at TRPV1 in rat isolated mesenteric arteries assessed as vasore... | 33257173 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33257173 | 10.1016/j.ejmech.2020.113042 | Transient receptor potential cation channel subfamily V member 1 | 2 |
Data from ChEMBL 36 via Core Engine